Search results for "BIOLOGICAL AGING"

showing 4 items of 4 documents

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

2020

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank p…

Netherlands Twin Register (NTR)LimfomesLOCIGenome-wide association studyDiseaseVARIANTSDISEASE0302 clinical medicineLeukocytestelomere lengthGWASGenetics(clinical)CàncerMendelian randomisationThyroid cancerGenetics (clinical)11 Medical and Health SciencesCancerGeneticsGenetics & HeredityRISK0303 health sciencesTelòmerage-related disease; biological aging; Mendelian randomisation; telomere length; Humans; Leukocytes; Nucleotides; Genome-Wide Association Study; TelomereNucleotidesmeta-analyysigenomiikkaGenomicsTelomereCANCER3. Good health030220 oncology & carcinogenesisbiological agingMENDELIAN RANDOMIZATION/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingMedical geneticsBiomarker (medicine)HEARTLymphomasLife Sciences & BiomedicineMedical Geneticsmedicine.medical_specialtyGENESDATABASEAge-related Disease ; Biological Aging ; Mendelian Randomisation ; Telomere LengthBiologyArticle03 medical and health sciencesSDG 3 - Good Health and Well-beingMendelian randomization/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_medicineGeneticsJournal ArticleHumans030304 developmental biologyMedicinsk genetikage-related diseaseScience & TechnologyCancer06 Biological Sciencesmedicine.diseaseTelomereGenòmicaikääntyminen1182 Biochemistry cell and molecular biologytelomeeritbiologicalGenome-Wide Association Study
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Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

2016

Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11- year follow-up. Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by q…

0301 basic medicineAgingmissing data not at randomTwinsphysical activitysix-minute walking testENVIRONMENTAL-FACTORSDevelopmental psychologyPhysical functioningMAXIMAL WALKING SPEEDSix-minute walking testLeukocytesMedicinetwin studyFinlandtelomereHERITABILITYWOMENTwin studyASSOCIATIONGeneral MedicineMiddle AgedTelomere3142 Public health care science environmental and occupational healthSurvival RateCARDIOVASCULAR-DISEASEbiological agingDisease ProgressionFemalePhysical activityfyysinen toimintakykyMotor ActivityArticleBiological aging03 medical and health sciencesWalking distanceAGEDiseases in TwinsHumansMissing data not at randomMotor activityMobility LimitationMETAANALYSISAgedPhysical activitybusiness.industryMORTALITYDisease progressionRepeated measures designHeritabilityTwin study030104 developmental biology3121 General medicine internal medicine and other clinical medicineGeriatrics and GerontologyDANISH TWINSbusinessPhysical functioningDemographyForecasting
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The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up

2021

Abstract Background Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between 4 epigenetic clocks (Horvath’s and Hannum’s DNAmAge and DNAm GrimAge and PhenoAge) and physical functioning during a 3-year follow-up. Method We studied 63- to 76-year-old women (N = 413) from the Finnish Twin Study on Aging. DNAm was measured from blood samples at baseline. Age acceleration (AgeAccel), that is, discrepancy between chronological age and DNAm age, was determined as residuals from linear model. Physical functioning was assessed under standardized laboratory conditions at b…

EpigenomicsAgingfyysinen toimintakykyEpigenesis Genetic03 medical and health sciences0302 clinical medicinePhysical functioningMedicineHumans030212 general & internal medicineEpigeneticsAssociation (psychology)030304 developmental biology0303 health sciencesbusiness.industryLinear modelRepeated measures designdNaMDNA MethylationMissing dataTwin studyDNA-metylaatioikääntyminenCross-Sectional Studiesepigenetiikkabiological aging3121 General medicine internal medicine and other clinical medicineFemaleGeriatrics and Gerontologybusinessepigenetic clockDemographyFollow-Up Studies
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Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging

2021

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MaleAgingLeisure timeliikuntaEpigenesis Genetic0302 clinical medicineTwins DizygoticMedicineOrthopedics and Sports MedicineYoung adult315 Sport and fitness sciencesAge FactorsMETHYLATIONMiddle AgedDNA-metylaatioepigenetiikkaComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFemaleSmoking statusSMOKINGfyysinen aktiivisuusAdultPhysical activityPhysical Therapy Sports Therapy and RehabilitationBIOLOGICAL AGINGYoung Adult03 medical and health sciencesLeisure ActivitiesSex FactorsHumansEpigeneticsExerciseOccupational HealthAgedModels GeneticBasic Sciencesbusiness.industrydNaMTwins Monozygotic030229 sport sciencesDNA MethylationTwin studyfyysinen kuormittavuusikääntyminentyön kuormittavuusbusinessLifestyle habitshuman activitiesQUANTITATIVE GENETICSDemography
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